Impotence
(ED; Erectile Dysfunction; Male Erectile Disorder)
Definition
Causes
Venous Leak
Neurovascular Function
- Nerve dysfunction—can reduce feeling in the penis, resulting in impotence
- Diabetes—interferes with nerve signals
- Complete loss of nighttime erections
- Hardening of the arteries—can cause reduced blood flow
- Peripheral neuropathy, spinal cord injury, and surgery—can damage nerves
- Side-effects from medications
| Blood Vessels and Nerves of Male Pelvis |
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Psychological Factors
Risk Factors
- Age: 65 and older
- Race: Hispanic
- Obesity
-
Medical conditions:
- Diabetes
- Hardening of arteries
- Chronic kidney disease
- Liver failure
- Peyronie's disease (bending of the penis caused by scar tissue)
- Endocrine disorders
- Neurological disorders (eg, multiple sclerosis, peripheral neuropathy, stroke)
- Hypertension
- Psychiatric disorders (eg, anxiety, depression)
-
Traumatic conditions:
- Vascular surgery
- Pelvic surgeries (particularly for prostate cancer)
- Spinal cord injury
-
Behaviors:
- Alcohol use
- Illegal drug use
- Anabolic steroid use
- Heavy smoking
- Interpersonal conflicts with a sexual partner
-
Medications:
- Antihypertensives—for high blood pressure
- Antihistamines—common as allergy medication
- Antidepressants
- Tranquilizers
- Antipsychotics
Diagnosis
- Hormone levels such as thyroid function tests
- Prolactin levels
- Testosterone levels
Nocturnal Penile Tumescence Testing
Imaging
Treatment
Medications
-
Phosphodiesterase inhibitors, such as:
- Sildenafil (Viagra)
- Tadalafil (Cialis)
- Vardenafil (Levitra)
- Oral testosterone, if you have low testosterone levels
- Alprostadil, either injected into the penis or inserted into the urethra as a suppository
Vacuum Devices
- Plastic cylinder for the penis
- Hand pump for pumping air out of the cylinder
- Elastic band for holding the erection after removal of the cylinder
Vascular Surgery
Penile Implants
| Penile Implant |
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Sex Therapy
- Ineffective sexual techniques
- Relationship problems
- Anxiety
- Depression
Prevention
- Take medications to manage blood pressure, diabetes, or depression.
- Ask your doctor about changing medications.
- Maintain a healthy weight.
- Eat a healthful diet.
- If you smoke, quit. Smoking is significantly associated with impotence in middle-aged and older men.
- Talk to a therapist or counselor.
RESOURCES
American Urological Association http://www.urologyhealth.org/
CANADIAN RESOURCES
Canadian Urological Association http://www.cua.org/
SexualityandU.ca http://www.sexualityandu.ca/
References
Erectile dysfunction. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated July 25, 2012. Accessed September 14, 2012.
Erectile dysfunction. National Institute of Diabetes & Digestive & Kidney Diseases website. Available at: http://kidney.niddk.nih.gov/kudiseases/pubs/ED/index.aspx . Updated March 28, 2012. Accessed September 14, 2012.
Erectile Dysfunction. American Urological Association Foundation website. Available at: http://www.urologyhealth.org/content/moreinfo/ed-factsheet.pdf . Updated 2009. Accessed September 14, 2012.
Erectile dysfunction. Familydoctor.org website. Available at: http://familydoctor.org/online/famdocen/home/men/reproductive/109.html . Updated December 2006. Accessed September 17, 2012.
Revision Information
- Reviewer: Adrienne Carmack, MD
- Review Date: 09/2012 -
- Update Date: 00/92/2012 -