Pre-eclampsia and Pregnancy-induced Hypertension
Principal Proposed Natural Treatments
Principal Proposed Natural Treatments
Other Proposed Natural Treatments
1 Atallah AN, Hofmeyr GJ, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev . 2002;CD001059. Review.
2 Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent pre-eclampsia. N Engl J Med. 1997;337:69-76.
3 Sanchez-Ramos L, Adair CD, Kaunitz AM, et al. Calcium supplementation in mild pre-eclampsia remote from term: a randomized double-blind clinical trial. Obstet Gynecol. 1995;85:915-918.
4 Hertz-Picciotto I, Schramm M, Watt-Morse M, et al. Patterns and determinants of blood lead during pregnancy. Am J Epidemiol. 2000;152:829-837.
5 Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet. 1999;354:810-816.
6 Gulmezoglu AM, Hofmeyr GJ, Oosthuisen MM. Antioxidants in the treatment of severe pre-eclampsia: an explanatory randomised controlled trial. Br J Obstet Gynaecol. 1997;104:689-696.
7 Sibai BM, Villar MA, Bray E. Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial. Am J Obstet Gynecol. 1989;161:115-119.
8 Spatling L, Spatling G. Magnesium supplementation in pregnancy. A double-blind study. Br J Obstet Gynaecol. 1988;95:120-125.
9 Kovacs L, Molnar BG, Huhn E, et al. Magnesium substitution in pregnancy. A prospective, randomized double-blind study [translated from German]. Geburtsh Frauenheilk. 1988;48:595-600.
10 Jonsson B, Hauge B, Larsen MF, et al. Zinc supplementation during pregnancy: a double blind randomised controlled trial. Acta Obstet Gynecol Scand. 1996;75:725-729.
11 Hunt IF, Murphy NJ, Cleaver AE, et al. Zinc supplementation during pregnancy: effects on selected blood constituents and on progress and outcome of pregnancy in low-income women of Mexican descent. Am J Clin Nutr. 1984;40:508-521.
12 Mahomed K, James DK, Golding J, et al. Zinc supplementation during pregnancy: a double blind randomised controlled trial. BMJ. 1989;299:826-830.
13 Moutquin JM, Garner PR, Burrows RF, et al. Report of the Canadian Hypertension Society Consensus Conference: 2. Nonpharmacologic management and prevention of hypertensive disorders in pregnancy. CMAJ. 1997;157:907-919.
14 Salvig JD, Olsen SF, Secher NJ. Effects of fish oil supplementation in late pregnancy on blood pressure: a randomized controlled trial. Br J Obstet Gynaecol. 1996;103:529-533.
15 Onwude JL, Lilford RJ, Hjartardottir H, et al. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Br J Obstet Gynaecol. 1995;102:95-100.
16 Bulstra-Ramakers MT, Huisjes HJ, Visser GH. The effects of 3 g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br J Obstet Gynaecol. 1995;102:123-126.
17 Olsen SF, Secher NJ. A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: indications from a 50-year-old controlled trial. Br J Nutr. 1990;64:599-609.
18 The Magpie Trial Collaborative Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet. 2002;359:1877-1890.
19 Rudnicki M, Frolich A, Rasmussen WF, et al. The effect of magnesium on maternal blood pressure in pregnancy-induced hypertension. A randomized double-blind placebo-controlled trial. Acta Obstet Gynecol Scand. 1991;70:445-450.
20 Moodley J, Norman RJ. Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. Prostaglandins Leukot Essent Fatty Acids. 1989;37:145-147.
21 Sharma JB, Kumar A, Kumar A, et al. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol Obstet . 2003;81:257-262.
22 Sibai BM. Prevention of pre-eclampsia: a big disapointment. Am J Obstet Gynecol . 1998;179:1275-1278.
23 Livingston JC, Livingston LW, Ramsey R, et al. Magnesium sulfate in women with mild pre-eclampsia: a randomized controlled trial. Obstet Gynecol . 2003;101:217-220.
24 Sibai BM. Magnesium sulfate prophylaxis in pre-eclampsia: lessons learned from recent trials. Am J ObstetGynecol . 2004;190:1520-1526.
25 Beazley D, Ahokas R, Livingston J et al. Vitamin C and E supplementation in women at high risk for pre-eclampsia: A double-blind, placebo-controlled trial. Am J Obstet Gynecol . 2005;192:520-521.
26 Rytlewski K, Olszanecki R, Korbut R et al. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in pre-eclampsia. Eur J Clin Invest . 2005;35:32-37.
27 Staff AC, Berge L, Haugen G et al. Dietary supplementation with l-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand . 2004;83:103-107.
28 Villar J, Abdel-Aleem H, Merialdi M et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol . 2006;194:639-649.
29 Rumbold AR, Crowther CA, Haslam RR et al. Vitamins C and E and the risks of pre-eclampsia and perinatal complications. N Engl J Med . 2006;354:1796-1806.
30 Rytlewski K, Olszanecki R, Korbut R et al. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in pre-eclampsia. Eur J Clin Invest . 2005;35:32-37.
31 Roes EM, Raijmakers MT, Boo TM et al. Oral N-acetylcysteine administration does not stabilise the process of established severe pre-eclampsia. Eur J Obstet Gynecol Reprod Biol . 2005 Oct 19 [Epub ahead of print].
32 Rumiris D, Purwosunu Y, Wibowo N et al. Lower rate of pre-eclampsia after antioxidant supplementation in pregnant women with low antioxidant status. Hypertens Pregnancy. 2006;25:241-253.
33 Bergel E, Barros AJ. Effect of maternal calcium intake during pregnancy on children blood pressure: a systematic review of the literature. BMC Pediatr . 2007 Mar 26 [Epub ahead of print].
34 Rumbold A, Duley L, Crowther C, Haslam R. Antioxidants for preventing pre-eclampsia. Cochrane Database Syst Rev. 2008;CD004227.
35 Villar J, Purwar M, Merialdi M, et al. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG. 2009;116:780-788.
36 Teran E, Hernandez I, Nieto B, et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet. 2009;105:43-5.
37 Vadillo-Ortega F, Perichart-Perera O, Espino S, et al. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011;342:d2901.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -